Pain Eaze (60 Day Supply)

Pain Eaze is a unique formula designed to regulate pain, support joint comfort, and promote immune health. Pain Eaze also provides plentiful amounts of antioxidants to support down-regulating inflammation, while relieving your pain.

WHY YOU SHOULD USE PAIN EAZE INSTEAD OF PAINKILLERS

Painkillers are dangerous! The number of deaths in America due to prescription painkiller overdose has more than tripled in the past decade, according to a new report from the Centers for Disease Control and Prevention (CDC). Approximately 15,000 people per year (about 40 per day) die from prescription painkillers. If that isn’t enough to caution you, there are many other reasons not to use painkillers. There are many other side effects of painkillers such as addiction, liver problems, and stomach issues. This is why you should use the all natural Pain Eaze instead.

COMMON USES OF PAIN EAZE

• Headaches
• Migraines
• Back Pain
• Knee Pain
• Fever Reducer

Pain Eaze is used to relieve general aches and pain. Many people use it for headaches, migraines and back pain. Others use it for knee pain, sports injuries, and fever. Another benefit is it contains antioxidants. Antioxidants have been proven to be beneficial by reducing inflammation, and pain. Pain Eaze is a safe alternative to painkillers that provides pain relief without the dangers of addiction, liver problems, and stomach issues.

APPLICATIONS

• Affects the Production of Arachidonic Acid-Derived Eicosanoids
• Supports Cytokine Balance
• Supports Joint Comfort
• Contains 40 mg Proprietary Bioflavonoid Berry Blend
• Supports Antioxidant Mechanisms

INGREDIENTS THAT WORK

WHITE WILLOW BARK (SALIX ALBA)
Willow bark has been used for thousands of years to help support eicosanoid and cytokine balance and to help relieve discomfort. (1-3) Willow bark is currently approved by the German Commission E and the European Scientific Cooperative on Phytotherapy (ESCOP) for these purposes. Willow bark is also recognized in the United States for its role in supporting joint comfort. (1) Willow bark contains glycosides, salicylates, flavonoids, tannins, aromatic compounds, and acids. A 2007 Cochrane review of the literature found moderate evidence that Salix alba positively affected eicosanoid metabolism and produced results that were comparable to those obtained by other commonly used compounds. Favorable results were obtained by other commonly used compounds. Favorable results were obtained when the Salix alba in the studies was standardized to 120 mg or 240 mg salicin, Pain Ease provides a standardized 120 mg does of salicin per serving.(4)

Various randomized placebo-controlled studies suggest that willow bark produces positive effects on joint discomfort. The usual dose of salicin is 240 mg per day, (5) which is the intake recommendation for Pain Eaze. Pharmacokinetic evaluations reveal that salicylic acid is the major metabolite of salicin, though other components of willow bark are believed to provide relief as well. (6) The mechanism of action of white willow bark appears to involve an effect on both arachidonic acid-derived eicosanoids and cytokine compounds.(7)

Willow bark is made from the bark of willow trees. It has been used for centuries as a pain reliever for general aches and pains. Many studies have proven the effectiveness of willow bark for pain. Willow bark contains salicin and other components that provide pain relief as well. This just proves that its nickname “Nature’s Aspirin” is well deserved.

5-LOXIN (BOSWELLIA)
This is a standardized Boswellia serrata extract enriched to 30% 3-O-afcetyl-11-keto-8-boswellic acid (AKBA), is ten times more concentrated than ordinary B serrata. Boswellia serrata is an ayurvedic herb whose principle constituents bosellic acid and alpha-boswellicu acid- may help maintain healthy leukotriene metabolism by reducing the activity of the enzyme 5-lipoxygenase. 5-lipoxygenanase (5-LOX) catalyzes the synthesis of unfavorable leukotrienes. A randomized, double-blind, placebo-controlled trial assessing the efficacy, safety, and tolerability of Boswellia extract produced statistically significant and clinically relevant decreases in knee discomfort, increases in knee flexion, and increases in walking distance.(9)

A randomized, double-blind, placebo-controlled study specifically designed with 5-Loxin resulted in statistically significant improvements in comfort and physical function and a significant reduction in matrix metalloproteinase (MMP) in synovial fluid. (10) MMP represents a class of enzymes that selectively hydrolyze peptide bonds and degrade structural proteins; they play a crucial role in the degradation of joint tissues. 5-Loxin shows significant inhibition against several MMPs. It helps prevent the formation of human recombinant TNF-a inducible MMPs, which further facilitates the maintenance of healthy cartilage and cell-cycle regulation.(11,12)

5-Loxin is proven to relieve inflammation, knee pain, increase knee flexion, and even increase walking distance. This is definitely a powerful ingredient in a pain reliever.

BERRYVIN (40 mg)
This contains a blend of blueberries, strawberries, escobillo, and cranberries, along with grape and pomegranate extracts. This bioflavonoid-rich berry powder provides polyphenols, anthocyanin, ellagic acid, and an antioxidant capacity of 4000 TE/g to fight free radicals It may also provide substantial antioxidant support for soft tissues. Bioflavonoids are thought to act synergistically to inhibit cycooxygenases, lipoxygenases, and phospholipase, ultimately supporting healthy eicosanoid metabolism and favorable cytokine balance.(13,14)

Berryvin contains a blend of many berries and extracts. The blend provides antioxidants which neutralize free radicals, support soft tissues, decrease inflammation, and relieve pain.


Count: 120 vegetarian capsules

Suggested use: Take two capsules daily, or as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

Storage: Keep in cool, dry place out of reach of children.

Does not contain: Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

References:

1. Natural Standard Database. Willow Bark (Salix Spp.). Somerville, MA: Natural Standard; 2012. http://naturalstandard.com/databases/ herbssupplements/willowbark.asp#undefined. Accessed August 2, 2012.
2. Singh AP. Salicin-A natural analgesic. Ethnobotanical Leaflets. 2003;1:1-4.http://opensiuc.lib.siu.edu/ebl/vol2003/iss1/8. Accessed August 2, 2012.
3. Fiebich BL, Appel K. Anti-inflammatory effects of willow bark extract. Clin Pharmacol Ther. 2003 Jul;74(1):96; author reply 96-7. [PMID: 12844141]
4. Gagnier JJ, van Tulder MW, Berman B, et al. Herbal medicine for low back pain: a Cochrane review. Spine. 2007 Jan 1;32(1):82-92. [PMID: 17202897]
5. Maroon JC, Bost JW, Maroon A. Natural anti-inflammatory agents for pain relief. Surg Neurol Int. 2010 Dec 13;1:80. [PMID: 21206541]
6. Schmid B, Kötter I, Heide L. Pharmacokinetics of salicin after oral administration of a standardised willow bark extract. Eur J Clin Pharmacol. 2001 Aug;57(5):387-91. [PMID: 11599656]
7. Khayyal MT, El-Ghazaly MA, Abdallah DM, et al. Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Arzneimittelforschung. 2005;55(11):677-87. [PMID: 16366042]
8. Safayhi H, Boden SE, Schweizer S, et al. Concentration-dependent potentiating and inhibitory effects of Boswellia extract on 5-Lipoxygenase product formation in stimulated PMNL. Planta Med. 2000 Mar;66(2):110-3. [PMID: 10763581]
9. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee—a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7. [PMID: 12622457]
10. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis Res Ther. 2008;10(4):R85. [PMID: 18667054]
11. Laila Impex Research Centre. 5-LOXIN® overview. PLT.Accessed August 8, 2012.
12. Roy S, Khanna S, Krishnaraju AV, et al. Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells issensitive to antiinflammatory Boswellia. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):653-60. [PMID: 16677108]
13. Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol. 1983 Apr 1;32(7):1141-8. [PMID: 6342623]
14. Kim HP, Son KH, Chang HW, et al. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci. 2004 Nov;96(3):229- 45. [PMID: 15539763]

https://www.ncbi.nlm.nih.gov/books/NBK493173/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC50756...
https://www.ncbi.nlm.nih.gov/books/NBK507245/


Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.