{"product_id":"citrus-c","title":"Bioflavonoid C","description":"\u003ch3 style=\"text-align: center;\"\u003e\u003cem\u003eFeaturing Vitamin C and Citrus Bioflavonoids for Enhanced Antioxidant and Immune Function\u003c\/em\u003e\u003c\/h3\u003e\n\u003cp\u003e Citrus C+ combines high-potency vitamin C with a standardized, full-spectrum, citrus bioflavonoid complex.\u003cspan\u003e Citrus C+ is formulated to provide antioxidant protection, enhance immune function, and support synthesis and function of collagen, carnitine, and neurotransmitters. Each capsule of \u003cmeta charset=\"utf-8\"\u003e Citrus C+  provides 500 mg of vitamin C and 500 mg of citrus bioflavonoid complex in a one-to-one ratio.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eAPPLICATIONS:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"p1\"\u003eAntioxidant support\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"p1\"\u003eHealthy Connective Tissue and Blood Vessel Synthesis\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"p1\"\u003eSupport of Normal Immune System Function\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"p1\"\u003eSynthesis of Carnitine, Neurotransmitters, and Collagen\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eHow Does Citrus C+ Work?  The Science...\u003c\/h3\u003e\n\u003cp\u003eBoth vitamin C and bioflavonoids have been extensively researched for their roles in supporting antioxidant and immune function. In addition, research indicates that vitamin C is required for the synthesis of collagen, neurotransmitters, and carnitine. Bioflavonoids appear to support healthy metabolism and cognition by functioning as cell-signaling agents.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C (ascorbic acid) is a water-soluble antioxidant vitamin that is essential to humans. While most mammals are able to synthesize vitamin C, humans must obtain it exogenously. Stress, smoking, pollution, radiation and heavy metal exposure, immune challenge, and temperature change all increase the human requirement for vitamin C.[1] Well-known functions of this ubiquitous vitamin include antioxidant protection from free radicals and oxidative processes; synthesis of collagen, carnitine, and neurotransmitters; adrenal support; and immune stimulation and support.[2-4] Vitamin C serves as a cofactor for several metabolic enzymes, including hydroxylase and oxygenase (hydroxylation reactions).*[5]\u003c\/p\u003e\n\u003cp\u003eVitamin C has long been recognized for its contribution to immune support.[3] Immune cells absorb and concentrate vitamin C. Immune cell activity, particularly T-cell function and phagocytosis, is found to be enhanced by this essential vitamin.[6-7] In early 1972, a randomized, double-blind, placebo-controlled study of 1000 subjects taking 1000 mg of vitamin C per day provided support for the use of vitamin C supplementation for common immune challenges. The study results revealed that the supplementation group missed significantly fewer days from work\/activities and had fewer days per episode of immune challenge; in addition, significantly more subjects taking vitamin C remained symptom free throughout the study.[8] Optimal intake of vitamin C for humans continues to be debated, though normal vitamin C synthesis in mammals such as the rat is calculated to be 26-58 mg\/kg\/day. Dr. Linus Pauling, in his 1970 article on evolution and vitamin C requirements, recommended a minimum intake of 2300 mg per 2500 kilocalorie intake per day for humans.*[9]\u003c\/p\u003e\n\u003cp\u003eVitamin C has far-reaching effects on a number of tissues in the body because it is required for the synthesis of collagen.[4] Collagen is a fundamental component of bones, tendons, ligaments, blood vessels, skin, gums, and joints. Ultimately, the health of these tissues depends on vitamin C. Energy generation from fatty acids is vitamin C-dependent as well since synthesis of carnitine (the molecule that shuttles long-chain fatty acids into the mitochondria) requires this versatile vitamin. Vitamin C is maintained in relatively high concentrations in the brain; it is essential to maintaining healthy mood and brain function because it facilitates conversion of dopamine to norepinephrine and enhances interneuronal communication.*[10]\u003c\/p\u003e\n\u003cp\u003eBioflavonoids (also known as flavonoids) are phytochemicals that are often found together with vitamin C in nature and are generally considered to be among the most important and interesting classes of biologically active compounds in contemporary research. More than 4000 bioflavonoids have been identified. Intake of flavonoids is associated with healthy cardiovascular status, the body’s normal response to inflammation, and positive microbial balance.*[11,12]\u003c\/p\u003e\n\u003cp\u003eCitrus bioflavonoids are commonly used in Europe for blood vessel and lymph system support. US practitioners utilize bioflavonoids in protocols to support tissue and joint comfort and the body’s normal response to inflammation,[13-15] respiratory[16,17] and eye health,[18] and maintenance of cardiovascular health.[19-21] Citrus bioflavonoids are able to cross the blood-brain barrier and have been recognized for their neuroprotective effects.[22] As cell-signaling agents, bioflavonoids are believed to support healthy cell growth and normal cell-life regulation, stimulate detoxification enzymes, decrease vascular cell adhesion molecules, increase vasodilation, and support healthy platelet function.*[23]\u003c\/p\u003e\n\u003cp\u003eThe combination of vitamin C and citrus bioflavonoids in Bioflavonoid C ensures that a wide range of metabolic functions will be supported.*\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCount: \u003c\/b\u003e90 capsules\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSuggested use:\u003c\/b\u003e\u003cspan\u003eTake one capsule daily, or as directed by your healthcare practitioner.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eConsult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eStorage:\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003eKeep in cool, dry place out of reach of children. \u003cb\u003e\u003cbr\u003e\u003cbr\u003eDoes not contain: \u003c\/b\u003eWheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eReferences:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e1. Whitney EN, Rolfes SR.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eUnderstanding Nutrition\u003c\/i\u003e. 8th ed. Belmont, CA: Wadsworth; 1998:321.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e2. NIH Office of Dietary Supplements. Dietary Supplement Fact Sheet: Vitamin C.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/ods.od.nih.gov\/factsheets\/VitaminC-HealthProfessional\/\"\u003ehttp:\/\/ods.od.nih.gov\/factsheets\/VitaminC-HealthProfessional\/\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp class=\"p1\"\u003e3. Schlueter AK, Johnston CS. Vitamin C: overview and update.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eJournal of Evidence-Based Complementary \u0026amp; Alternative Medicine (JEBCAM)\u003c\/i\u003e. 2011; 16(1):49-57.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/chp.sagepub.com\/content\/16\/1\/49.full.pdf+html\"\u003ehttp:\/\/chp.sagepub.com\/content\/16\/1\/49.full.pdf+html\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp class=\"p1\"\u003e4. Linus Pauling Institute. Vitamin C.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/lpi.oregonstate.edu\/infocenter\/vitamins\/vitaminC\/\"\u003ehttp:\/\/lpi.oregonstate.edu\/infocenter\/vitamins\/vitaminC\/\u003c\/a\u003e. Updated November 2009. \u003c\/p\u003e\n\u003cp class=\"p1\"\u003e5. Naidu KA. Vitamin C in human health and disease is still a mystery? An overview.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eNutr J\u003c\/i\u003e. 2003 Aug 21;2:7. [PMID: 14498993]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e6. Chatterjee M, Dikshit M. Vitamin C mediated resistance to pathogenic invasions: possible implications during infections for better health.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eProceedings of the National Academy of Sciences India\u003c\/i\u003e. Section B, Biological Sciences. 2009; 79(1):15-25.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e7. Ströhle A, Wolters M, Hahn A. Micronutrients at the interface between inflammation and infection—ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eInflamm Allergy Drug Targets\u003c\/i\u003e. 2011 Feb;10(1):54-63. [PMID: 21184650]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e8. Anderson TW, Reid DB, Beaton GH. Vitamin C and the common cold: a double-blind trial.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eCan Med Assoc J\u003c\/i\u003e. 1972 Sep 23;107(6):503-8. [PMID: 5057006]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e9. Pauling L. Evolution and the need for ascorbic acid.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eProc Natl Acad Sci USA\u003c\/i\u003e. 1970 Dec;67(4):1643-8. [PMID: 5275366]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e10. Rebec GV, Pierce RC. A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eProg Neurobiol\u003c\/i\u003e. 1994 Aug;43(6):537-65. Review. [PMID: 7816935]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e11. Tripoli E, La Guardia M, Giammanco S, et al. Citrus flavonoids: Molecular structure, biological activity and nutritional properties: A review.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eFood Chemistry\u003c\/i\u003e. 2007; 104(2):466-79.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e12. Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ePharmacol Rev\u003c\/i\u003e. 2000 Dec;52(4):673-751. Review. [PMID: 11121513]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e13. Guardia T, Rotelli AE, Juarez AO, et al. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rats.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eFarmaco\u003c\/i\u003e. 2001 Sep;56(9):683-7. [PMID: 11680812]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e14. Rotelli AE, Guardia T, Juárez AO, et al. Comparative study of flavonoids in experimental models of inflammation.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ePharmacol Res\u003c\/i\u003e. 2003 Dec;48(6):601-6. [PMID: 14527825]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e15. Lin N, Sato T, Takayama Y,et al. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eBiochem Pharmacol\u003c\/i\u003e. 2003 Jun 15;65(12):2065-71. [PMID: 12787887]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e16. Pijnenburg MW, Hofhuis W, Hop WC, et al. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eThorax\u003c\/i\u003e. 2005 Mar; 60(3):215-8. [PMID: 15741438]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e17. Lee NK, Choi SH, Park SH, et al. Antiallergic activity of hesperidin is activated by intestinal microflora.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ePharmacology\u003c\/i\u003e. 2004 Aug;71(4):174- 80. [PMID: 15240993]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e18. Majumdar S, Srirangam R. Potential of the bioflavonoids in the prevention\/treatment of ocular disorders.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eJ Pharm Pharmacol\u003c\/i\u003e. 2010 Aug;62(8):951-65. Review. [PMID: 20663029]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e19. Wright B, Spencer JP, Lovegrove JA, et al. Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eCardiovasc Res\u003c\/i\u003e. 2012 Nov 1. [Epub ahead of print] [PMID: 23024269]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e20. Mulvihill EE, Huff MW. Citrus flavonoids and the prevention of atherosclerosis.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eCardiovasc Hematol Disord Drug Targets\u003c\/i\u003e. 2012 Oct 1. [Epub ahead of print] [PMID: 23030447]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e21. Soory M. Nutritional antioxidants and their applications in cardiometabolic diseases.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eInfect Disord Drug Targets\u003c\/i\u003e. 2012 Nov 16. [Epub ahead of print] [PMID: 23167714]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e22. Hwang SL, Shih PH, Yen GC. Neuroprotective effects of citrus flavonoids.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eJ Agric Food Chem\u003c\/i\u003e. 2012 Feb 1;60(4):877-85. doi: 10.1021\/ jf204452y. Epub 2012 Jan 23. Review. [PMID: 22224368]\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e23. Linus Pauling Institute. Micronutrient Information Center. Flavonoids.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/lpi.oregonstate.edu\/infocenter\/phytochemicals\/flavonoids\/\"\u003ehttp:\/\/lpi.oregonstate.edu\/infocenter\/phytochemicals\/flavonoids\/\u003c\/a\u003e. Updated June 2008. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eDisclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e","brand":"Celarity","offers":[{"title":"Default Title","offer_id":33827818963079,"sku":"NHC139","price":35.97,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0294\/5446\/7207\/files\/celarity-bioflavonoid-c-1253880564.webp?v=1786472891","url":"https:\/\/celarityhealth.com\/products\/citrus-c","provider":"Celarity","version":"1.0","type":"link"}