Berberine ER by Celarity (60 day supply)

Berberine ER
IMPROVE INSULIN SENSITIVITY AND LOWER BLOOD SUGAR NATURALLY
Now 5X More Bio-Available

A compound called Berberine is one of the most effective natural supplements available. Berberine has been shown to lower blood sugar, cause weight loss, and improve heart health. One of the main actions of Berberine is to activate the AMPK enzyme, which is sometimes referred to as the "metabolic master switch". 

Many studies show that berberine can significantly reduce blood sugar levels in individuals with type 2 diabetes. In fact, its effectiveness is comparable to the popular diabetes drug metformin.

If you want to improve your insulin sensitivity, lower blood sugar naturally, and maintain a healthy body weight, then look to the nutrient berberine. Berberine ER by Celarity is a natural insulin sensitivity supplement designed to help your body regulate insulin levels and balance your blood sugar naturally.  Berberine IR was reformulated to Berberine ER and is now 5x more bioavailable.

What Is BERBERINE ER?

Berberine ER is designed to support insulin activity and glucose metabolism. Berberine ER features dihydroberberine (DHB), the natural, highly bioactive form of berberine.  Research also suggests a role for berberine in supporting normal A1C levels. We recommend that you combine Berberine ER with a low carb diet (like the Heal Yourself Diet) for optimal results. 

APPLICATIONS

• Supports Glucose Metabolism
• Improves Insulin Sensitivity
• Promotes Natural Weight Loss
• Supports Healthy Blood Lipid Metabolism
• Assists the Body in Maintaining Normal Levels of HbA1c
• Positively Influences Adipocyte Differentiation and PPAR Expression Associated with Adipogenesis
• Provides Antioxidant Support
• Decreases Insulin Resistance, making the blood sugar lowering hormone insulin more effective
• Increases Glycolysis/Balances Blood Sugar Levels
• Decrease Sugar Production in the liver
• Slows the Breakdown of Carbohydrates in the Gut
• Increases the Number of Beneficial Bacteria in the Gut

BERBERINE

Berberine is known as an alkaloid, and plants containing berberine have traditionally been used for their various health-promoting properties. Research has demonstrated that berberine helps regulate glucose and lipid metabolism, positively influences cell signaling, provides antioxidant support, and impacts immune health.[1-3] Of more recent interest is the influence of berberine on cardiometabolic health, including its effects on adenosine monophosphate-activated protein kinase (AMPK), gene transcription and signaling factors that influence adipose tissue differentiation, and hemoglobin A1c (HbA1c) levels.

Adenosine Monophosphate-Activated Protein Kinase (AMPK)

As the primary enzyme that induces an intracellular cascade of events, AMPK is responsible for maintaining and replenishing cellular energy stores. AMPK activation stimulates glucose uptake and fat oxidation while it suppresses lipogenesis and gluconeogenesis. Cumulatively, AMPK activation leads to beneficial metabolic states in liver, muscle, and peripheral tissues. Of the natural products known to activate AMPK, berberine is one of the most prominent. AMPK activation by berberine was reported as early as 2006.[4] Since that time, berberine-mediated AMPK activation has been repeatedly demonstrated, and this mechanism is thought to be central to the beneficial effects on glucose metabolism, insulin sensitivity, cytokine activity, and cardiovascular health observed in patients taking berberine.[3,5,6]

Adipocyte Differentiation and PPAR-Gamma Expression

In vitro, berberine positively influences fat cell size.[7] This effect is significant because it has been reported that fat tissue composed of a high number of small fat cells is more sensitive to insulin than fat tissue (with the same lipid content) composed of a low number of large fat cells. Berberine has also been shown to downregulate the adipogenesis-regulating transcription factors peroxisome proliferator-activated receptor (PPAR) gamma2 and CCAAT/enhancer-binding protein (C/EBP) alpha in preadipocytes isolated from human omental fat.[7] This downregulating effect on PPARs has been observed in other in vitro work and in animal research as well.[8-11] In a human study, individuals taking 900 mg/d of berberine for three months showed decreases in waist circumferences and BMI (body mass index) as well as significant decreases in leptin levels, leptin/adiponectin ratio, and the homeostatic model assessment of insulin resistance (HOMA-IR). There were no significant changes in adiponectin levels.[7]

Hemoglobin A1c (HbA1c)

Also known as glycated hemoglobin or glycosylated hemoglobin, HbA1c serves as the definitive measure of a person’s average blood sugar level for a three-month period. Maintaining HbA1c within a healthy range is an important aspect of cardiometabolic wellness. Recent studies on berberine show that doses of 1,000 to 3,000 mg/d have a positive effect on HbA1c levels. Yin et al demonstrated that 1,500 mg/d of berberine had significant beneficial effects on HbA1c, glucose metabolism, and triglyceride metabolism.[1] In a randomized placebo-controlled study (n = 116), 1,000 mg/d of berberine significantly decreased HbA1c and had positive effects on blood lipid metabolism.[2] This desirable effect on HbA1c by berberine has also been observed in animals.[8]

Celarity Company Statement
Celarity's Berberine ER is a state of the art product that is pharmaceutical grade and only to be sold by licensed practitioners. Celarity prides itself on being on the forefront of innovation in the natural health and holistic healing field. Celarity also prides itself on working with innovative doctors who are disruptors in the health care field.

Count: 60 capsules

Recommended Usage: Take one to two capsules daily with food, or as directed by your healthcare practitioner.

Cautions: Consult your healthcare practitioner prior to use. Individuals taking medications, especially medications that are metabolized by cytochrome P450 enzymes or that affect blood glucose, should discuss potential interactions with their healthcare practitioner. Do not use if you are pregnant, nursing, or trying to conceive. Do not use if tamper seal is damaged.

Does Not Contain: Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

References:

1. Imenshahidi M, Hosseinzadeh H. Phytother Res. 2019;33(3):504-523. doi:10.1002/ptr.6252 

2. Zhang Q, Xiao X, Feng K, et al. Evid Based Complement Alternat Med. 2011;2011:924851. doi:10.1155/2011/924851 

3. Yin J, Xing H, Ye J. Metabolism. 2008;57(5):712-17. doi:10.1016/j.metabol.2008.01.013 

4. Feng R, Shou JW, Zhao ZX, et al. Sci Rep. 2015;5:12155. doi:10.1038/srep12155 

5. Turner N, Li JY, Gosby A, et al. Diabetes. 2008;57(5):1414-1418. doi:10.2337/db07-1552 

6. Han J, Lin H, Huang W. Med Sci Monit. 2011;17(7):RA164-RA167. doi:10.12659/msm.881842 

7. Zhou L, Yang Y, Wang X, et al. Metabolism. 2007;56(3):405-412. doi:10.1016/j.metabol.2006.10.025 

8. Wang Q, Zhang M, Liang B, et al. PLoS One. 2011;6(9):e25436. doi:10.1371/journal.pone.0025436 

9. Chen C, Yu Z, Li Y, et al. Am J Chin Med. 2014;42(5):1053-1070. doi:10.1142/S0192415X14500669 

10. Gaba S, Saini A, Singh G, et al. Bioorg Med Chem. 2021;38:116143. doi:10.1016/j.bmc.2021.116143 

11. Wolf PG, Devendran S, Doden HL, et al. BMC Microbiol. 2021;21(1):24. doi:10.1186/s12866-020-02020-1 

12. Moon J, Ratliff K, Hagele A, et al. Nutrients. 2021;14(1):124. doi:10.3390/nu14010124

13. http://diabetes.diabetesjournals.org/content/55/8/2256.full

14. https://www.ncbi.nlm.nih.gov/pubmed/10409121

15. https://www.ncbi.nlm.nih.gov/pubmed/25607236

16. https://www.ncbi.nlm.nih.gov/pubmed/25498346

17. https://www.ncbi.nlm.nih.gov/pubmed/18442638

18. https://www.ncbi.nlm.nih.gov/pubmed/25861268

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.